How Hydroxychloroquine Fights Malaria

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Hydroxychloroquine tablet, a derivative of chloroquine, is used to combat malaria by interfering with the parasite's ability to digest hemoglobin. Malaria parasites, such as Plasmodium falciparum, thrive in red blood cells and consume hemoglobin, producing toxic heme as a byproduct. Hydroxychloroquine enters the red blood cells and concentrates in the parasite's food vacuole, where it inhibits the heme polymerase enzyme. This inhibition prevents the conversion of toxic heme into hemozoin, a non-toxic substance, leading to the accumulation of toxic heme. The buildup of toxic heme ultimately kills the parasite, thereby treating the malaria infection. Hydroxychloroquine's effectiveness against malaria has been crucial in controlling this life-threatening disease.